Natural products inspired drug discovery

The Sharma Lab is extremely appreciative for the funding agencies that allow us to conduct research. Those agencies are: ACS Petroleum Research Fund (ACS-PRF),  Oklahoma Center for the Advancement of Science and Technology (OCAST), Oklahoma NSF-EPSCOR, American Society of Pharmacognosy (ASP), and American Society for Engineering Education SMART (Science Mathematics and Research for Transformation) Fellowship.

Chemist's in the Sharma Laboratory are able to quickly and confidently identify products in a complex reaction mixture via TLC/MS. Within minutes after developing a TLC this instrument can identify the molecular weight of each individual spot on the TLC plate.  The Sharma Lab believes this instrument alone has increased productivity tremendously and is a key component to our daily research efforts. Take a look at the video above of the instrument in action!

external collaborations

Advion tlc mass spectrometry

Funding agencies and acknowledgements

To advance the utility of our synthetic compounds, we have established multi-disciplinary collaborations with Memorial Sloan-Kettering, Mount Sinai, Vanderbilt University, ICSN-CNRS in France, and University of Oklahoma Health Sciences Center. This combination of expertise in natural product isolation, organic synthesis, medicinal chemistry, computational chemistry and molecular pharmacology is insurmountable.